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pepperchip ® infectious disease epitope microarray  (PEPperPRINT gmbh)

 
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    PEPperPRINT gmbh pepperchip ® infectious disease epitope microarray
    Peptide <t>microarray</t> analysis captures clinically relevant pathogen antibody profiles. A ) Study design. IgG antibody binding to specific epitopes was quantified in serum samples and aqueous humour (AqH) samples from paediatric uveitis patients and controls using the <t>PEPperCHIP®</t> Infectious Disease <t>Epitope</t> Microarray. B ) A 17-year old patient with acute retinal necrosis [ARN] due to intraocular infection with HSV-1 was profiled as positive control (confirmed by PCR of AqH and local intraocular antibody production). C ) Plot of IgG antibody intensities against 3697 linear peptides on the microarray in paired AqH and serum of the ARN patient from b and a non-inflammatory cataract control of 11 years old. Each (grey) dot represents the mean IgG intensity for a single peptide. Cutoff values characterizing the positive signals of the microarray are shown by the horizontal (serum) and vertical (AqH) lines. D ) Heatmap showing the HSV-1 peptides and amino acid sequences, and their respective levels of IgG in the ARN patient and control. The 12 peptides that were positively detected in AqH are highlighted.
    Pepperchip ® Infectious Disease Epitope Microarray, supplied by PEPperPRINT gmbh, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pepperchip ® infectious disease epitope microarray/product/PEPperPRINT gmbh
    Average 90 stars, based on 1 article reviews
    pepperchip ® infectious disease epitope microarray - by Bioz Stars, 2026-04
    90/100 stars

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    1) Product Images from "Paediatric autoimmune uveitis is associated with intraocular antibodies against Epstein–Barr virus Nuclear Antigen 1 (EBNA-1)"

    Article Title: Paediatric autoimmune uveitis is associated with intraocular antibodies against Epstein–Barr virus Nuclear Antigen 1 (EBNA-1)

    Journal: eBioMedicine

    doi: 10.1016/j.ebiom.2025.105681

    Peptide microarray analysis captures clinically relevant pathogen antibody profiles. A ) Study design. IgG antibody binding to specific epitopes was quantified in serum samples and aqueous humour (AqH) samples from paediatric uveitis patients and controls using the PEPperCHIP® Infectious Disease Epitope Microarray. B ) A 17-year old patient with acute retinal necrosis [ARN] due to intraocular infection with HSV-1 was profiled as positive control (confirmed by PCR of AqH and local intraocular antibody production). C ) Plot of IgG antibody intensities against 3697 linear peptides on the microarray in paired AqH and serum of the ARN patient from b and a non-inflammatory cataract control of 11 years old. Each (grey) dot represents the mean IgG intensity for a single peptide. Cutoff values characterizing the positive signals of the microarray are shown by the horizontal (serum) and vertical (AqH) lines. D ) Heatmap showing the HSV-1 peptides and amino acid sequences, and their respective levels of IgG in the ARN patient and control. The 12 peptides that were positively detected in AqH are highlighted.
    Figure Legend Snippet: Peptide microarray analysis captures clinically relevant pathogen antibody profiles. A ) Study design. IgG antibody binding to specific epitopes was quantified in serum samples and aqueous humour (AqH) samples from paediatric uveitis patients and controls using the PEPperCHIP® Infectious Disease Epitope Microarray. B ) A 17-year old patient with acute retinal necrosis [ARN] due to intraocular infection with HSV-1 was profiled as positive control (confirmed by PCR of AqH and local intraocular antibody production). C ) Plot of IgG antibody intensities against 3697 linear peptides on the microarray in paired AqH and serum of the ARN patient from b and a non-inflammatory cataract control of 11 years old. Each (grey) dot represents the mean IgG intensity for a single peptide. Cutoff values characterizing the positive signals of the microarray are shown by the horizontal (serum) and vertical (AqH) lines. D ) Heatmap showing the HSV-1 peptides and amino acid sequences, and their respective levels of IgG in the ARN patient and control. The 12 peptides that were positively detected in AqH are highlighted.

    Techniques Used: Peptide Microarray, Binding Assay, Microarray, Infection, Positive Control, Control

    Broad intraocular antibody repertoire against EBV in the paediatric population . A) Mean IgG antibody intensity per peptide in AqH and serum of our cohort. Cutoff values characterizing the positive signals of the microarray are shown by the horizontal (serum) and vertical (AqH) lines. Positively detected peptides are colour-coded. B) Heatmap showing the IgG antibody intensities in the AqH against the detected peptides in patients and controls. Peptides are annotated by pathogen species and peptide cluster. A dendrogram indicates the average distance between the peptides of the clusters. C) Heatmap of the amino acid sequence similarity of the peptides in a and b according to peptide similarity index from little similarity (0) to identical sequence (1). The dendrograms indicate Ward's minimum variance between peptides of the clusters.
    Figure Legend Snippet: Broad intraocular antibody repertoire against EBV in the paediatric population . A) Mean IgG antibody intensity per peptide in AqH and serum of our cohort. Cutoff values characterizing the positive signals of the microarray are shown by the horizontal (serum) and vertical (AqH) lines. Positively detected peptides are colour-coded. B) Heatmap showing the IgG antibody intensities in the AqH against the detected peptides in patients and controls. Peptides are annotated by pathogen species and peptide cluster. A dendrogram indicates the average distance between the peptides of the clusters. C) Heatmap of the amino acid sequence similarity of the peptides in a and b according to peptide similarity index from little similarity (0) to identical sequence (1). The dendrograms indicate Ward's minimum variance between peptides of the clusters.

    Techniques Used: Microarray, Sequencing



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    Peptide <t>microarray</t> analysis captures clinically relevant pathogen antibody profiles. A ) Study design. IgG antibody binding to specific epitopes was quantified in serum samples and aqueous humour (AqH) samples from paediatric uveitis patients and controls using the <t>PEPperCHIP®</t> Infectious Disease <t>Epitope</t> Microarray. B ) A 17-year old patient with acute retinal necrosis [ARN] due to intraocular infection with HSV-1 was profiled as positive control (confirmed by PCR of AqH and local intraocular antibody production). C ) Plot of IgG antibody intensities against 3697 linear peptides on the microarray in paired AqH and serum of the ARN patient from b and a non-inflammatory cataract control of 11 years old. Each (grey) dot represents the mean IgG intensity for a single peptide. Cutoff values characterizing the positive signals of the microarray are shown by the horizontal (serum) and vertical (AqH) lines. D ) Heatmap showing the HSV-1 peptides and amino acid sequences, and their respective levels of IgG in the ARN patient and control. The 12 peptides that were positively detected in AqH are highlighted.
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    Peptide microarray analysis captures clinically relevant pathogen antibody profiles. A ) Study design. IgG antibody binding to specific epitopes was quantified in serum samples and aqueous humour (AqH) samples from paediatric uveitis patients and controls using the PEPperCHIP® Infectious Disease Epitope Microarray. B ) A 17-year old patient with acute retinal necrosis [ARN] due to intraocular infection with HSV-1 was profiled as positive control (confirmed by PCR of AqH and local intraocular antibody production). C ) Plot of IgG antibody intensities against 3697 linear peptides on the microarray in paired AqH and serum of the ARN patient from b and a non-inflammatory cataract control of 11 years old. Each (grey) dot represents the mean IgG intensity for a single peptide. Cutoff values characterizing the positive signals of the microarray are shown by the horizontal (serum) and vertical (AqH) lines. D ) Heatmap showing the HSV-1 peptides and amino acid sequences, and their respective levels of IgG in the ARN patient and control. The 12 peptides that were positively detected in AqH are highlighted.

    Journal: eBioMedicine

    Article Title: Paediatric autoimmune uveitis is associated with intraocular antibodies against Epstein–Barr virus Nuclear Antigen 1 (EBNA-1)

    doi: 10.1016/j.ebiom.2025.105681

    Figure Lengend Snippet: Peptide microarray analysis captures clinically relevant pathogen antibody profiles. A ) Study design. IgG antibody binding to specific epitopes was quantified in serum samples and aqueous humour (AqH) samples from paediatric uveitis patients and controls using the PEPperCHIP® Infectious Disease Epitope Microarray. B ) A 17-year old patient with acute retinal necrosis [ARN] due to intraocular infection with HSV-1 was profiled as positive control (confirmed by PCR of AqH and local intraocular antibody production). C ) Plot of IgG antibody intensities against 3697 linear peptides on the microarray in paired AqH and serum of the ARN patient from b and a non-inflammatory cataract control of 11 years old. Each (grey) dot represents the mean IgG intensity for a single peptide. Cutoff values characterizing the positive signals of the microarray are shown by the horizontal (serum) and vertical (AqH) lines. D ) Heatmap showing the HSV-1 peptides and amino acid sequences, and their respective levels of IgG in the ARN patient and control. The 12 peptides that were positively detected in AqH are highlighted.

    Article Snippet: Paired AqH and serum samples were profiled using the PEPperCHIP ® Infectious Disease Epitope Microarray ( PEPperPRINT TM , Heidelberg, Germany) ( A).

    Techniques: Peptide Microarray, Binding Assay, Microarray, Infection, Positive Control, Control

    Broad intraocular antibody repertoire against EBV in the paediatric population . A) Mean IgG antibody intensity per peptide in AqH and serum of our cohort. Cutoff values characterizing the positive signals of the microarray are shown by the horizontal (serum) and vertical (AqH) lines. Positively detected peptides are colour-coded. B) Heatmap showing the IgG antibody intensities in the AqH against the detected peptides in patients and controls. Peptides are annotated by pathogen species and peptide cluster. A dendrogram indicates the average distance between the peptides of the clusters. C) Heatmap of the amino acid sequence similarity of the peptides in a and b according to peptide similarity index from little similarity (0) to identical sequence (1). The dendrograms indicate Ward's minimum variance between peptides of the clusters.

    Journal: eBioMedicine

    Article Title: Paediatric autoimmune uveitis is associated with intraocular antibodies against Epstein–Barr virus Nuclear Antigen 1 (EBNA-1)

    doi: 10.1016/j.ebiom.2025.105681

    Figure Lengend Snippet: Broad intraocular antibody repertoire against EBV in the paediatric population . A) Mean IgG antibody intensity per peptide in AqH and serum of our cohort. Cutoff values characterizing the positive signals of the microarray are shown by the horizontal (serum) and vertical (AqH) lines. Positively detected peptides are colour-coded. B) Heatmap showing the IgG antibody intensities in the AqH against the detected peptides in patients and controls. Peptides are annotated by pathogen species and peptide cluster. A dendrogram indicates the average distance between the peptides of the clusters. C) Heatmap of the amino acid sequence similarity of the peptides in a and b according to peptide similarity index from little similarity (0) to identical sequence (1). The dendrograms indicate Ward's minimum variance between peptides of the clusters.

    Article Snippet: Paired AqH and serum samples were profiled using the PEPperCHIP ® Infectious Disease Epitope Microarray ( PEPperPRINT TM , Heidelberg, Germany) ( A).

    Techniques: Microarray, Sequencing